Zithrocare 200/Zithrocare 500 Adverse Reactions

Zithrocare 200: Serious: angioedema and cholestatic jaundice, nausea, vomiting, diarrhea or abdominal pain.
Multiple-dose regimen: diarrhea/loose stools, nausea, abdominal pain.
Cardiovascular: Palpitations and chest pain.
Gastrointestinal: Dyspepsia, flatulence, vomiting, melena and cholestatic jaundice.
Genitourinary: Monilia, vaginitis and nephritis.
Nervous system: Dizziness, headache, vertigo and somnolence.
General: Fatigue.
Allergic: Rash, photosensitivity and angioedema.
Post marketing experience: Allergic: Arthralgia, edema, urticaria and angioedema.
Cardiovascular: Arrythmias, including ventricular tachycardia and hypotension. There have been reports of QT prolongation and Torsade de Pointes.
Gastrointestinal: Anorexia, constipation, dyspepsia, flatulence, vomiting, diarrhea, pseudomembranous colitis, pancreatitis, oral candidiasis, pyloric stenosis and tongue discoloration.
General: Asthenia, paresthesia, fatigue, malaise and anaphylaxis.
Genitourinary: Interstitial nephritis, acute renal failure and vaginitis.
Hematopoietic: Thrombocytopenia.
Liver/Biliary: Abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis and hepatic failure.
Nervous system: Convulsions, dizziness/vertigo, headache, somnolence, hyperactivity, nervousness, agitation and syncope.
Psychiatric: Aggressive reaction and anxiety.
Skin/Appendages: Pruritus and serious skin reaction including erythema multiforme, Stevens-johnson syndrome, and toxic epidermal necrolysis.
Special Senses: Hearing disturbances including hearing loss, deafness and/or tinnitus and reports of taste/smell perversion and/or loss.
Zithrocare 500: Gastrointestinal disturbances are the most frequent adverse effect but those are usually mild. Headache may occur and taste disturbances have been reported rarely.